汤磊

       汤磊，博士，区域高发疾病方向糖尿病机制与干预研究课题学术带头人。入选国家百千万人才工程并授予“有突出贡献中青年专家”荣誉称号，教育部新世纪优秀人才，贵州省核心专家，国贴获得者。贵州省药学会常务理事，承担国家及省部级项目20余项，横向合作项目14项。发表研究论文150篇，其中SCI论文40篇。以第一发明人申请或获得发明专利10余项，获贵州省科技进步一等奖及三等奖各1项。培养博硕士生30余名。

研究方向

化学创新药的研究和仿制药开发

代表性论文

1. Ting-Ting Wu，Qing-Qing Guo，Zi-Li Chen，Li-Li Wang，Yao Du，Rui Chen，Yuan-Hu Mao，Sheng-Gang Yang，Jing Huang，Jian-Ta Wang，Ling Wang，Lei Tang*，Ji-Quan Zhang*. Design，synthesis and bioevaluation of novel subsitituted triazines as potential dual PI3K/mTOR inhibitors. Eur J Med Chem. 2020;204:112637.

2. Xing-Lan Wang#，Xue Bai#，Chun-Feng Wu，Yong-Xi Dong，Min Zhang，Ling-Ling Fan，Lei Tang*，Yuan-Yong Yang*，Ji-Quan Zhang*. Direct C（sp3）-H Sulfonylation and Sulfuration Reactions of Isoquinoline-1,3（2H,4H）-diones under Metal-free Conditions. Asian Journal Of Organic Chemistry. DOI：10.1002/ajoc.202000668.

3. Ji-Quan Zhang#,*, Shu-Min Li#, Chun-Feng Wu, Xing-Lan Wang, Ting-Ting Wu, Yao Du, Yuan-Yong Yang, Ling-Ling Fan, Yong-Xi Dong, Jian-Ta Wang, Lei Tang*. The Synthesis of Symmetrical 3,3-Disubstituted Oxindoles by Phosphine-Catalyzed γ/γ-Addition of Oxindoles with Allenoates. Catalysis Communications. 2020;138:105838.

4. Yuan-Yong Yang#,*, Guo Yang#, Cheng Cheng, Ying-Xian Li, Ji-Quan Zhang, Wei Feng, Yong-Long Zhao, Lei Tang*. Catalyst-free Cleavage of Amide and C-O Double Bond for the Diastereoselective Synthesis of Trifluoromethyl-Containing Dihydrooxazole Derivatives. Org Lett. 2019;21(7):2236-2240.

5. Ji-Quan Zhang, Shu-Min Li, Xiao Ma, Gang Zhong, Rui Chen, Xiao-Shuang Li，Gao-Feng Zhu，Bo Zhou，Bing Guo，Hao-Shu Wu，Lei Tang*. Discovery of tetrahydrocarbazoles with potent hypoglycemic and hypolipemic activities. Eur J Med Chem. 2018;150:102-112.