洪伟

洪伟，博士、教授、博士研究生导师，贵州省（第六批）高层次创新型人才（“千层次”）。2014年获中国科学院大学博士学位，留学美国奥本大学（Auburn University）。担任中国药理学会抗衰老与老年痴呆专业委员会常务青年委员，中华医学会细胞生物学会青年委员、贵州省医学会医学伦理学分会委员和美国&中国微生物学会会员。担任mbio, Frontiers in Genetics, Frontiers in Microbiology, Microbiology Spectrum, Biotechnology for biofuels, International Journal of Molecular Medicine, Journal of Basic Microbiology和组织工程等国内外期刊审稿人。近年来，先后主持国家自然科学基金3项。以第一或通讯作者在国内外期刊发表论文30余篇，其中SCI论文15余篇，授权发明专利3项，至今培养硕士生10名，博士生1名。

研究方向:

1.病原微生物基因功能研究与宿主互作

2.微生物肿瘤治疗

3.纳米材料治疗口腔疾病

主持的研究项目：

（1）国家自然科学基金面上项目，slpA-cwp66基因座对艰难梭菌抗逆性与致病力的影响及其机制研究(在研)

（2）贵州省科学技术厅(重点项目)，艰难梭菌黏附素蛋白(Cwp66)介导细胞黏附和炎症机制研究(在研)

（3）国家自然科学基金青年基金，艰难梭菌细胞粘附因子参与毒素基因表达调控研究(结题)

（4）国家自然科学基金地区基金，TeI3c/4c嗜热二型内含子单插入热点碱基组成规律及其应用研究(结题)

代表性论文

23. Ying Yang, Luhong Shu, Ling Ping, Junyi Yang, Ruirui Shao, Yumei Cheng, Shanshan Luo, Xinglang Wei, Zhizhong Guan, Zhenghong Che , Jian Liao, Xiaolan Qi, Guzhen Cui1,Wei Hong. Genomic analysis of a novel ST11(PR34365)Clostridioides difficilestrain isolated from the human fecal of a CDI patient in Guizhou, China, Open Life Sciences (Accepted). (Corresponding author)

22. Y. Yang, T. Huang, J. Yang, R. Shao, L. Shu, P. Ling, Y. Lu, W. Ma, J. Liao, Z. Guan, X. Qi, G. Cui,W. Hong, The Sigma Factor σ 54 (rpoN) functions as a Global Regulator of Antibiotic Resistance, Motility, Metabolism, and Virulence inClostridioides difficile, Front. Microbiol. 16 (2025). https://doi.org/10.3389/fmicb.2025.1569627. (Corresponding author)

21. D. Hua, Q. Yang, X. Li, X. Zhou, Y. Kang, Y. Zhao, D. Wu, Z. Zhang, B. Li, X. Wang, X. Qi, Z. Chen, G. Cui,W. Hong, The combination ofClostridium butyricumandAkkermansia muciniphilamitigates DSS-induced colitis and attenuates colitis-associated tumorigenesis by modulating gut microbiota and reducing CD8+ T cells in mice, mSystems. 10 (2025) e01567-24. https://doi.org/10.1128/msystems.01567-24. (Corresponding author)

20. J. Zheng, Y. Li, T. Zhang, Y. Fu, P. Long, X. Gao, Z. Wang, Z. Guan, X. Qi,W. Hong, Y. Xiao, Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury: PERK as a potential target for intervention, Neural Regeneration Research. 20 (2025) 1455–1466. https://doi.org/10.4103/NRR.NRR-D-23-00794. (Corresponding author)

19. S. Luo, R. Shao, Y. Hong, T. Zhang, Q. Zhou, Q. Zhou, F. Rao, X. Zhao, Y. Dong, R. Zhu, P. Ling, G. Cui, Z. Guan, P. Luo, Y. He, X. Qi, J. Liao,W. Hong, Identifying the oral microbiome of adolescents with and without dental fluorosis based on full-length 16S rRNA gene sequencing, Front. Microbiol. 15 (2024) 1296753. https://doi.org/10.3389/fmicb.2024.1296753. (Corresponding author)

18. 邵瑞瑞;周青帅;崔古贞;廖健;程玉梅;官志忠;齐晓岚;洪伟,污水中肺炎克雷伯氏菌噬菌体的分离及其生物学特征、基因组分析,四川大学学报(自然科学版). (2024) 326–337. https://doi.org/10.19907/j.0490-6756.2024.046004. (Corresponding author)

17. Guzhen Cui#, Dengxiong Hua# Xingxing Zhao#, Jia Zhou, Ying Yang, Tingyu Huang, Xinxin Wang, Yan Zhao, Ting Zhang, Jian Liao, Zhizhong Guan, Peng Luo,Zhenghong Chen*, Xiaolan*,Wei Hong*. A New EBS2b-IBS2b Base Paring (A− 8/T− 8) Improved the Gene-Targeting Efficiency of Thermotargetron inEscherichia coli. Microbiology Spectrum. 2023 Feb 21:e03159-22. (Corresponding author)

16. 杨君仪,鲍江舰,邵瑞瑞,张婷,廖健,程玉梅,官志忠,齐晓岚,陈峥宏,崔古贞,洪伟, CD630＿27900基因缺失显著降低艰难拟梭菌自溶速率、毒力及对酸和抗生素的耐受性,微生物学报. 63 (2023) 2440–2455. https://doi.org/10.13343/j.cnki.wsxb.20220731.(Corresponding author)

15. 鲍江舰;杨君仪;邵瑞瑞;张婷;廖健;程玉梅;官志忠;齐晓岚;陈峥宏;洪伟;崔古贞,fliL基因显著影响艰难拟梭菌运动功能及产孢能力,生物工程学报. (2023) 1578–1595. https://doi.org/10.13345/j.cjb.220765. (卓越期刊，Corresponding author)

14. Hong, W., Zhang, J., Cui, G., Zhou, Q., Wang, P., and Wang, Y. (2022). “Highly Efficient Genome Editing inClostridium difficileUsing the CRISPR-Cpf1 System,” in Recombineering Methods in Molecular Biology., ed. C. R. Reisch (New York, NY: Springer US), 175–187. doi: 10.1007/978-1-0716-2233-9_12. (Book Chapter) (First author)

13. Q. Zhou#, F. Rao#, Z. Chen, Y. Cheng, Q. Zhang, J. Zhang, Z. Guan, Y. He, W. Yu,G. Cui*, X. Qi*,W. Hong*, Thecwp66Gene Affects Cell Adhesion, Stress Tolerance, and Antibiotic Resistance inClostridioides difficile, Microbiol Spectr. (2022) e02704-21.https://doi.org/10.1128/spectrum.02704-21. (Corresponding author)

12. 周青帅;赵行行;李冬梅;崔古贞;陈峥宏;任玮;齐晓岚;洪伟,大肠埃希菌密度感应调节子qseC基因失活突变株构建及其生物学特性,实用医学杂志. (2022) 288–294.

11. 崔古贞,周青帅,程钦全,饶凤琴,程玉梅,田艳,张婷,陈峥宏,廖健,官志忠,齐晓岚,吴棋,洪伟,艰难拟梭菌PaLoc致病决定区基因座敲除突变株转录组学分析及其减毒验证,中华预防医学杂志. 56 (2022) 8. (卓越期刊，Corresponding author)

10. Wei Hong*, Fengqin Rao, Xingxing Zhao, Zhenyang Guo, Yumei Chen , Bing Wang, Zhizhong Guan, Xiaolan Qi*. An inexpensive anaerobic chamber for the genetic manipulation of strictly anaerobic bacteria. J. Anaerobe. 2021,69,102349. (First and Corresponding author)

9. XL Wang, YX Deng, YM Gao, YT Dong, F Wang, ZZ Guan,W Hong*, XL Qi*, Activation of α7 nAChR by PNU-282987 improves synaptic and cognitive functions through restoring the expression of synapticassociated proteins and the CaM-CaMKII-CREB signaling pathway, Aging-US, In production, 2020. (Corresponding author)

8. 洪伟,万雯,崔古贞,官志忠,齐晓岚,禹文峰(2020).艰难梭菌基因编辑技术研究进展.生物工程学报36, 210–225.（卓越期刊）(First and Corresponding author)

7. 赵行行,程玉梅,吴昌学,任玮,饶凤琴,周倩,崔古贞,齐晓岚*，洪伟* (2020).温度诱导Targetron系统用于大肠杆菌高效基因失活.生物工程学报36, 1659–1671.（卓越期刊）(Corresponding author)

6. W. Hong#, *,J. Yang#, Y. Cheng, X. Huang, F. Rao, T. Zhang, P. Wang, J. Liao, X. Qi, Z. Guan, Z. Chen, G. Cui, Bacteria co-colonizing withClostridioides difficilein two asymptomatic patients, Open Life Sciences. 14 (2019) 628–637. https://doi.org/10.1515/biol-2019-0071. (First and Corresponding author)

5. X.L. Huang, L.Y. Huang, Y.T. Cheng, F. Li, Q. Zhou, C. Wu, Q.H. Shi, Z.Z. Guan, J. Liao*,W. Hong*, Zoledronic acid inhibits osteoclast differentiation and function through the regulation of NF-κB and JNK signalling pathways, Int. J. Mol. Med. 44 (2019) 582–592. doi:10.3892/ijmm.2019.4207.(Corresponding author)

4. J. Zhang, W. Zong,W. Hong, Z.T. Zhang, Y. Wang, Exploiting endogenous CRISPR-Cas system for multiplex genome editing inClostridium tyrobutyricumand engineer the strain for high-level butanol production, Metab. Eng. 47 (2018) 49–59. doi:10.1016/j.ymben.2018.03.007. (Other author)

3. S. Wang,W. Hong, S. Dong, Z.T. Zhang, J. Zhang, L. Wang, Y. Wang*, Genome engineering ofClostridium difficileusing the CRISPR-Cas9 system, Clin. Microbiol. Infect. 24 (2018) 1095–1099. doi:10.1016/j.cmi.2018.03.026. (Other author)

2. W. Hong#, *,Y. Cheng#, F. Rao, J. Yang, G. Cui, Z. Chen, J. Liao, X. Huang, J. Zhang, P. Wang, S. Wang, Y. Wang, Z. Guan, X. Qi*, Co-infection ofClostridioides (Clostridium) difficileGMU1 andBacillus cereusGMU2 in one patient in Guizhou, China, Anaerobe. 54 (2018) 159–163. doi:10.1016/j.anaerobe.2018.08.004. (First and Corresponding author)

1. W. Hong#,J. Zhang#, G. Cui, L. Wang, Y. Wang*, Multiplexed CRISPR-Cpf1-Mediated Genome Editing inClostridium difficiletoward the Understanding of Pathogenesis ofC. difficileInfection, ACS Synth. Biol. 7 (2018) 1588–1600. doi:10.1021/acssynbio.8b00087. (First author)

联系方式：

通信地址：贵州省贵安新区安康大道6号贵州医科大学

E-mail: hongwei_2015@hotmail.com; hongwei@gmc.edu.cn.