谭俊,教授、博士研究生导师、医学博士、美国密歇根大学&南佛罗里达大学博士后、贵州省十百千万引进人才、现任贵州医科大学教授;曾任美国南佛罗里达大学医学院神经病学终身教授,美国神经病学协会与免疫学协会等12家专业协会主席及会员,《Nature Communications》、《Journal of Neuroscience》等19家国际知名杂志审稿人;《Scientific Reports》、《American Journal of Translational Research》等四本国际杂志编委;2003年获中国海外杰出青年科学家;2007年被授予Robert A. Silver发育神经生物学Silver 讲席教授(Robert A. Silver Endowed Chair),2007-2019年 Sliver讲席教授,终身教授。自2006年以来主持和参与美国国立医学研究院(NIH)、美国国家衰老研究所(NIA)、美国国家心理卫生组织(NIMH)等科研课题32项,从美国国家卫生和健康研究院获得以及其他同行评议的基金共计超过2000万美元,并授予优异奖;在美国及国际权威杂志发表原创论文约170篇(SCI),如《SCIENCE》、《Nature Neuroscience》、《Nature Communications》、《Nature Medicine》、《EMBO J》、《PNAS》、《Molecular Psychiatry》、《Biological Psychiatry》、《J Neuroscience》、《JBC》、《J Immunology》;申请专利20项,获得授权15项。培养毕业博士生8名、博士后约30名。
研究方向
1. 阿尔茨海默病(AD)发病的机制及药物开发研究
2. 大脑衰老的分子生物学机制研究
3. 精神分裂症(Schizophrenia)& 自闭症 (Autism)分子免疫学机制的研究
代表性论文
1. Tan J#, Town T#, Paris D#, Mori T, Crawford F, Mattson M, Flavell R, Mullan M. The CD40-CD40L interaction leads to microglial activation after β-amyloid stimulation. SCIENCE. 1999; 286(17): 2352-2355.
2. Tan J, Town T, Crawford F, Mori T, DelleDonne A, Crescentini R, Obregon D, Flavell RA and Mullan MJ. Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice. Nat Neurosci. 2002; 5(12): 1288-1293.
3. Nikolic V, Bai Y, Obregon D, Hou H, Mori T, Zeng J, Ehrhart J, Shytle D, Giunta B, Morgan D, Town T*, Tan J*. Transcutaneous β-amyloid immunization of transgenic Alzheimer’s mice reduces cerebral β-amyloid deposits without T-cell infiltration and microhemorrhage. Proc Natl Acad Sci U S A. 2007; 104:2507-2512.
4. Obregon D, Hou HY, Deng J, Giunta B, Tian J, Darlington D, Shahaduzzaman MD, Zhu YY, Mori T, Mattson M and Tan J*. sAPPα Suppresses β-Secretase Activity and Amyloid-β-Peptide Generation. Nat Commun. 2012; 3: 777.
5. Sawmiller D, Habib A, Hou H, Mori T, Fan A, Tian J, Zeng J, Giunta B, Sanberg PR, Mattson MP, Tan J*. A Novel Apolipoprotein E Antagonist Functionally Blocks Apolipoprotein E Interaction with N-terminal Amyloid Precursor Protein, reduces β-Amyloid-Associated Pathology, and Improves Cognition. Biol Psychiatry. 2019; 86(3): 208-220.
授权发明专利 (从15项专利中选择)
1. Jun TAN (谭俊), Tampa, FL (US); Paul R. Sanberg, Spring Hill, FL (US)],HUCBC TREATMENT OF AMYLOID-ASSOCIATED DISEASE, 2018.8.7, USA,US9402870B2
2. Jun TAN(谭俊), FL (US); Brian Nelson GIUNTA, FL (US); Song LI, FL (US); Huayan HOU, FL (US); Paul R. SANBERG Spring Hill, FL (US)], AMYLOID PRECURSOR PROTEIN (APP) BASED (ß-SECRETASE) INHIBITOR PEPTIDES, AND METHODS OF USE, 2018.3.7, US9926354B2
3. Paula C. Bickford, FL (US); Cyndy Davis Sanberg, FL (US); Jun TAN(谭俊), FL (US); Paul Sanberg, FL (US); R. Douglas Shytle, FL (US)],Composition and Methods of Improving Cognitive Performance,2017.11.28, US9827285B1
4. Jun TAN (谭俊), FL (US); Adam John Smith, FL (US); Roland Douglas Shytle, FL (US)] Lithium co-crystals and an additional neuropsychiatric agent for treatment of neuropsychiatric disorders, 2017.03.28, US9603869B2
5. Gary Arendash, Prescott, AZ (US); Chuanhai Cao, Temple Terrence, FL (US); Jun TAN(谭俊), Tampa, FL (US)] Prevention, Treatment, and Diagnosis of Alzheimer's Disease through Electromagnetic Field Exposure, 2016.01.19, US9238149B2
6. Jun TAN (谭俊), FL (US); Deyan Luo, Saranac Lake, NY (US); Douglas Shytle, Largo, FL (US)] Luteolin and Diosmin/Diosmetin as Novel STAT3 Inhibitor for treating Autism, 2014.07.15, US8778894B2
联系方式:
通信地址:贵州医科大学分子生物学重点实验室
E-mail: 744905403@qq.com
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